Selenium supplementation over 6 months reverse the progression of precancerous lesions of the cervix.
The cervical cancer is preceded by a state “precancerous” cervical intraepithelial neoplasia. Laboratories, together with the health authorities now encourage young girls to be vaccinated against this risk, a situation denounced by doctors. Especially that there could be an alternative to these vaccines by Iranian researchers who publish their findings in the British Journal of Nutrition, selenium supplementation prevents the evolution of precancers in carcinoma.
Selenium is an essential element present in trace which is involved in several important metabolic pathways including the antioxidant protection via activation of specialized enzymes, glutathione peroxidases. Brazil nuts are particularly rich in selenium, and certain seafood (oysters, tuna …).
The selenium intake is recommended in the range of 1 microgram per kilo of weight.In this paper, the researchers describe the effects of long-term supplementation with selenium on brain tissue and the metabolic profile of patients with cervical intraepithelial neoplasia (CIN). This randomized, double-blind, placebo-cons, included 58 women with a diagnosis of CIN. For six months, 28 of them were given a placebo and the other 28 200 mcg of selenium supplements a day.
Intraepithelial cervical neoplasia corresponds to changes in the squamous cells of the cervix. It is not cancer, but a precancerous condition that, untreated, can progress to carcinoma in about 30 to 50% of cases. Intracervical neoplasia, as well as infection with HPV is a risk factor for the disease, have no symptoms. Only regular Pap smear can detect early cell changes.
After six months of supplementation, 88% of women had a regression of the neoplasm, against 56% in the placebo group.
Positive metabolic effects were observed: supplementation resulted in a decrease of 0.37 mmol / L of fasting glucose (against 0.07 in the placebo group) and a decrease of 28.8 pmol / L insulin against 13.2 in the placebo group.
The antioxidant capacity of the blood also increased in people supplemented with selenium: 186.1 mmol / L + against 42.8 in the placebo group. There was also a significant decrease in malondialdehyde, a marker of oxidative stress.
Therefore, the selenium supplementation in patients with cervical neoplasia enables regression of the neoplasm and improves metabolic profile.